OUR VISION
We are building a leading, next generation precision medicine company utilizing the power of ultrasound to enable targeted drug delivery in oncology
KEY FOCUS AREA
Focus on Oncology
We are united in the mission:
ACT® against pancreatic cancer
Latest company news:
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Preclinical collaboration with Agenus Inc.
EXACT Therapeutics and Agenus announce preclinical collaborations in pancreatic cancer models
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EXACT Therapeutics is granted patent in the UK
The granted patent covers EXACT’s proprietary Acoustic Cluster Therapy in combination with immunotherapy in cancer and autoimmune disease patients.
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EXACT Therapeutics to present at ISTU 2024
EXACT-Tx will give two presentations at the upcoming 23rd Annual International Symposium on Therapeutic Ultrasound, in Taipei, Taiwan.
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Full focus on Phase 2 pancreatic cancer trial
Our pipeline
Our technology
The Key differentiation of ACT® is:
ACT® has a biomechanical mode of action to increase the uptake of co-administered drugs from blood vessels into the surrounding (cancer) tissue, without damaging the cells within the capillary walls; unlike sonoporation, ACT® does not create holes in the epithelial cell membranes of the capillary wall.
With ACT®, the drug can reach IOO microns which is 10 layers of cells away from capillary with an ongoing pump effect that lasts for minutes.
Reproducible and signifcant uptake through targeted delivery into tumours and across the blood brain barrier (BBB).
A very strong toxicology package:
including most recently, in relation to BBB opening where no extravasation of red blood cells was observed throughout the ACT® procedure in a preclinical rodent model.
Uses a bespoke dual frequency transducer with a standard ultrasound scanner to activate and enhance the clusters at the target tumour site. Compatible with existing ultrasound systems widely available in clinics/hospitals worldwide.
No drug reformulation required.
ACT® relies on ultrasound settings well within safe and approved ranges.
State of the art navigation system in development to ensure ACT® is delivered accurately at a targeted site