Scientific Publications

  • Poster Presentation at ISTU 2024

    Poster titled "Mechanistic Insights of Acoustic Cluster Therapy (ACT) - Understanding ACT Bubble Creation and Oscillation Behaviour.

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  • Additional promising clinical data from EXACT Therapeutics’ ongoing ACTIVATE study presented at AACR Annual Meeting

    Poster presented at American Association for Cancer Research, April 9, 2024

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  • Real-Time Intravital Imaging of Acoustic Cluster Therapy−Induced Vascular Effects in the Murine Brain

    Ultrasound in Medicine & Biology | January 2023

    DOI: doi.org/10.1016/j.ultrasmedbio.2023.01.007

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  • Effect of ACT® combined with chemotherapy in a patient-derived xenograft mouse model of pancreatic cancer

    Journal of Controlled Release | December 2022

    DOI: https://doi.org/10.1016/j.jconrel.2022.11.016

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  • Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation

    Ultrasound in Medicine & Biology | June 2022

    DOI: doi.org/10.1016/j.ultrasmedbio.2022.05.009

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  • Acoustic Cluster Therapy (ACT®) enhances accumulation of polymeric micelles in the murine brain

    International Journal of Controlled Release | September 2021

    DOI: doi.org/10.1016/j.jconrel.2021.07.019

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  • Theranostic Attributes of Acoustic Cluster Therapy and Its Use for Enhancing the Effectiveness of Liposomal Doxorubicin Treatment of Human Triple Negative Breast Cancer in Mice

    Frontiers in Pharmacology | February 2020

    DOI: dx.doi.org/10.3389/fphar.2020.00075

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  • Therapeutic Dose Response of Acoustic Cluster Therapy in Combination With Irinotecan for the Treatment of Human Colon Cancer in Mice

    Frontiers in Pharmacology | November 2019

    DOI: dx.doi.org/10.3389/fphar.2019.01299

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  • Efficient Enhancement of Blood–Brain Barrier Permeability Using Acoustic Cluster Therapy (ACT®)

    Theranostics | January 2017

    DOI: dx.doi.org/10.7150/thno.16577

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  • Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma

    Journal of Controlled Release | November 2016

    DOI: dx.doi.org/10.1016/j.jconrel.2016.11.019

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  • Safety assessment in rats and dogs of Acoustic Cluster Therapy, a novel concept for ultrasound mediated, targeted drug delivery

    Pharmacology Research & Perspectives | October 2016

    DOI: dx.doi.org/10.1002/prp2.274

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  • Acoustic Cluster Therapy for better treatment of solid tumors

    Journal of Controlled Release | August 2016

    DOI: dx.doi.org/10.1016/j.jconrel.2016.07.010

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  • Acoustic Cluster Therapy ACT®) — preclinical proof of principle for local drug delivery and enhanced uptake

    Journal of Controlled Release | February 2016

    DOI: dx.doi.org/10.1016/j.jconrel.2016.01.023

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  • Acoustic Cluster Therapy (ACT®) – in vitro and ex vivo measurement of activated bubble size distribution and temporal dynamics

    Ultrasound in Medicine and Biology | January 2016

    DOI: dx.doi.org/10.1016/j.ultrasmedbio.2015.12.011

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  • A novel concept for ultrasound mediated, targeted drug delivery – ACT®

    International Journal of Pharmaceutics | November 2015

    DOI: dx.doi.org/10.1016/j.ijpharm.2015.09.047

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  • Acoustic Cluster Therapy (ACT®) enhances the therapeutic efficacy of paclitaxel and Abraxane® for treatment of human prostate adenocarcinoma in mice

    Journal of Controlled Release | August 2016

    DOI: dx.doi.org/10.1016/j.jconrel.2016.06.018

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