Biomedicine & Pharmacotherapy

Acoustic cluster therapy mediated enhancement of [68Ga]Ga-PSMA-617 in a murine glioblastoma multiforme model verified by simultaneous PET/MRI

Melina Mühlenpfordt, Morten Smedsrud Wigen, Piyapan Suwattananuruk, Chandra Karunakaran, Marvin Jones, Jack Marshall, Mallika Keralapura, Einar Sulheim, Efat Muhammad Arshad, Stine Figenschau, Rodrigo Berzaghi, Rune Sundset, Bhaskar Ramamurthy, Angel Moldes-Anaya, Mathias Kranz

Biomedicine & Pharmacotherapy, August 2026, Article: 119682, Volume: Volume 201

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Journal of Nuclear Medicine

Acoustic Cluster Therapy (ACT®) mediated Enhancement of [Ga]Ga-PSMA-617 in a Murine Glioblastoma Multiforme (GBM) Model verified with simultaneous PET/MRI.

Melina Mühlenpfordt, Morten Wigen, Piyapan Suwattananuruk, Chandra Karunakaran, Marvin Jones, Jack Marshall, Mallika Keralapura, Stine Figenschau, Rodrigo Berzaghi, Rune Sundset, Bhaskar Ramamurthy, Angel Moldes-anaya and Mathias Kranz

Journal of Nuclear Medicine June 2025, 66 (supplement 1) 251045;

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Poster presentation at ASCO GI

Poster Title: A phase 2 study to investigate the efficacy and safety of acoustic cluster therapy with modified FOLFIRINOX in patients with locally advanced pancreatic cancer

Poster #: TPS795

In collaboration with HonorHealth Research Institute, Scottsdale, AZ, United States

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Poster presentation at ESMO 2025

Poster title: First-in-Human Study of Acoustic Cluster Therapy consisting of PS101 combined with Chemotherapy and insonation in Patients with Liver Metastases of Colorectal Cancer Origin 

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Poster presentation at AACR 2025

Poster title: A Phase 2 study to investigate the efficacy and safety of Acoustic Cluster Therapy with modified FOLFIRINOX in patients with locally advanced pancreatic cancer

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Poster Presentations at CICON 2025

Title: Acoustic Cluster Therapy (ACT) increases Anti-PD1 checkpoint inhibitor uptake in prostate cancer in mice. In collaboration with NTNU, the Norwegian University of Science and Technology

Title: Evaluation of the immunostimulatory potential of Acoustic Cluster Therapy (ACT®) in melanoma and breast cancer models in mice. In collaboration with ICR, the Institute of Cancer Research, UK

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Poster Presentation at ISTU 2025

Poster: Accoustic Cluster Therapy (ACT) enhanced accumulation of radiopharmaceutical in a Murine Glioblastoma Multiform Model.

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Poster Presentation at ISTU 2024

Poster titled "Mechanistic Insights of Acoustic Cluster Therapy (ACT) - Understanding ACT Bubble Creation and Oscillation Behaviour.

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Additional promising clinical data from EXACT Therapeutics’ ongoing ACTIVATE study presented at AACR Annual Meeting

Poster presented at American Association for Cancer Research, April 9, 2024

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Real-Time Intravital Imaging of Acoustic Cluster Therapy−Induced Vascular Effects in the Murine Brain

Ultrasound in Medicine & Biology | January 2023

DOI: doi.org/10.1016/j.ultrasmedbio.2023.01.007

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Effect of ACT® combined with chemotherapy in a patient-derived xenograft mouse model of pancreatic cancer

Journal of Controlled Release | December 2022

DOI: https://doi.org/10.1016/j.jconrel.2022.11.016

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Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation

Ultrasound in Medicine & Biology | June 2022

DOI: doi.org/10.1016/j.ultrasmedbio.2022.05.009

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Acoustic Cluster Therapy (ACT®) enhances accumulation of polymeric micelles in the murine brain

International Journal of Controlled Release | September 2021

DOI: doi.org/10.1016/j.jconrel.2021.07.019

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Theranostic Attributes of Acoustic Cluster Therapy and Its Use for Enhancing the Effectiveness of Liposomal Doxorubicin Treatment of Human Triple Negative Breast Cancer in Mice

Frontiers in Pharmacology | February 2020

DOI: dx.doi.org/10.3389/fphar.2020.00075

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Therapeutic Dose Response of Acoustic Cluster Therapy in Combination With Irinotecan for the Treatment of Human Colon Cancer in Mice

Frontiers in Pharmacology | November 2019

DOI: dx.doi.org/10.3389/fphar.2019.01299

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Efficient Enhancement of Blood–Brain Barrier Permeability Using Acoustic Cluster Therapy (ACT®)

Theranostics | January 2017

DOI: dx.doi.org/10.7150/thno.16577

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Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma

Journal of Controlled Release | November 2016

DOI: dx.doi.org/10.1016/j.jconrel.2016.11.019

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Safety assessment in rats and dogs of Acoustic Cluster Therapy, a novel concept for ultrasound mediated, targeted drug delivery

Pharmacology Research & Perspectives | October 2016

DOI: dx.doi.org/10.1002/prp2.274

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Acoustic Cluster Therapy for better treatment of solid tumors

Journal of Controlled Release | August 2016

DOI: dx.doi.org/10.1016/j.jconrel.2016.07.010

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Acoustic Cluster Therapy ACT®) — preclinical proof of principle for local drug delivery and enhanced uptake

Journal of Controlled Release | February 2016

DOI: dx.doi.org/10.1016/j.jconrel.2016.01.023

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Acoustic Cluster Therapy (ACT®) – in vitro and ex vivo measurement of activated bubble size distribution and temporal dynamics

Ultrasound in Medicine and Biology | January 2016

DOI: dx.doi.org/10.1016/j.ultrasmedbio.2015.12.011

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A novel concept for ultrasound mediated, targeted drug delivery – ACT®

International Journal of Pharmaceutics | November 2015

DOI: dx.doi.org/10.1016/j.ijpharm.2015.09.047

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Acoustic Cluster Therapy (ACT®) enhances the therapeutic efficacy of paclitaxel and Abraxane® for treatment of human prostate adenocarcinoma in mice

Journal of Controlled Release | August 2016

DOI: dx.doi.org/10.1016/j.jconrel.2016.06.018

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